新型口服胶囊可在体内完成胰岛素注射,让糖尿病患者免受扎针之苦

注射胰岛素已经成为了许多糖尿病患者日常生活的一部分,但对很多见到针头就害怕的人来说,这一过程可谓痛苦。如今,他们的福音来了,来自麻省理工学院(MIT)、哈佛医学院等机构的研究人员共同开发了一种能够在患者胃内注射胰岛素的药物胶囊,有望让部分患者免去打针的过程,仅需吞下胶囊,就能在无痛无感中完成药物注射。

新型口服胶囊可在体内完成胰岛素注射,让糖尿病患者免受扎针之苦

(图片来源:MIT 官网)

一般来说,口服是一个相对更加轻松的用药方式,但是以胰岛素为代表的许多化合物易遭到胃酸破坏,因此一直以来多通过注射的方式给药。这种新胶囊的出现,让部分糖尿病患者通过口服进行治疗成为可能,同时也能够避免一些由皮肤注射带来的风险。这一成果近日发表在了Science 杂志上。

根据 MIT 官网介绍,胶囊外部主要由可生物降解的聚合物和不锈钢成分制成,胶囊内有一个由胰岛素制成的微针、一个不锈钢金属弹簧、还有一个由糖制成的圆盘挡住弹簧。当胶囊到达胃部,糖在胃酸中溶解,释放弹簧将微针推入胃内壁。

值得一提的是,由于胃壁没有疼痛感受器,因此研究人员认为患者将不会感受到注射的过程。

为了确保将药物微针注射入胃壁,而不是留在胃部,研究人员需要让胶囊保持出针口对着胃壁,为此研究人员将胶囊设计成了与“橡果”类似的形状,让胶囊在胃里滚动后,仍能在胃的底部保持出针口对着胃壁的状态。这样无论胶囊以何种方式落在胃里,针头都能接触到胃壁,研究人员表示。

新型口服胶囊可在体内完成胰岛素注射,让糖尿病患者免受扎针之苦

(图片来源:MIT 官网)

一旦将针尖注射进胃壁,胰岛素能以特定速率溶解在患者体内,而速率的大小则可以根据治疗需要,在制备胶囊环节进行灵活调整。而当胰岛素制成的针尖完全溶解,其他部分则都能安全地通过消化系统排出。

研究人员表示,动物实验表明这些胶囊能够提供足量胰岛素,其降低血糖的效果与皮肤注射相当。此外,他们还证实,该装置也可用于其他蛋白质药物的输送,例如替代皮肤注射对用于癌症治疗的抗体、激素等药物进行给药。

在家猪身上进行的实验中,研究人员已经通过喂食这种胶囊,成功向猪体内注射了 300 微克的胰岛素。观察发现,在治疗一周后,动物胃组织没有损伤迹象,也没有产生任何其他副作用。

而最近,他们已经将胶囊携带药物的剂量增加到了 5 毫克,这个剂量将可满足 1 型糖尿病患者的用药需求。

西班牙圣地亚哥大学(University of Santiago de Compostela)的生物制药和制药技术教授 Maria José Alonso 将这种新型胶囊描述为一种可以让许多患者受益的“全新的技术”。

如今,MIT 团队正继续与制药公司诺和诺德(Novo Nordisk)合作,对该技术进行进一步开发,以优化胶囊的制造工艺。他们认为,该胶囊可以用于任何必须进行注射的蛋白质药物,如用于治疗类风湿性关节炎或炎症性肠病的免疫抑制剂。

研究的参与者 Giovanni Traverso 教授说:“我们的目的是为了让患者更简单地接受药物治疗,特别是注射治疗。“他表示,胰岛素是只是一个最典型的例子,许多其他药物也能通过同样的方式进行注射。

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